Three-Dimensional 1060-nm OCT: Choroidal Thickness Maps in Normal Subjects and Improved Posterior Segment Visualization in Cataract Patients

PURPOSE. To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS. Axial lengths (ALs) and 45 degrees fundus photographs were acquired from 64 eyes (34 healthy subjects, 19 to 80 years, ametropia +3 to -10 D). 3D 1060-nm OCT was performed over a 36 degrees x 36 degrees field of view with similar to 7-mu m axial resolution and up to 70 frames/s (512 A-scans/frame). ChT maps between retinal pigment epithelium and the choroidal-scleral interface, were generated and statistically analyzed. A further 30 eyes (19 subjects), with cataracts assessed with the LOCS III scale, were imaged with 3D 1060-nm OCT and 800-nm OCT, and visualization of the posterior segment was compared qualitatively. RESULTS. In 64 eyes, ChT maps displayed a thickness decrease with increasing AL. Subfoveal ChT was 315 +/- 106 mu m (mean +/- SD), negatively correlated with AL (R-2 = -0.47, P < 0.001). Averaged ChT maps of eyes with AL < 23.39 mm showed an increased ChT in an area similar to 1500 mu m inferior, compared with subfoveal ChT. Eyes with AL > 24.5 mm showed a larger variation and a thicker ChT superiorly than inferiorly. Reduced signal strength in cataractous eyes was found in 65% of the 800-nm OCT images, but in only 10% of the 1060-nm OCT images. CONCLUSIONS. The imaging performance of 3D 1060-nm OCT is unique, producing maps that show the variation in ChT over the entire field of view, in relation to axial length. This imaging system has the potential of visualizing a novel clinical diagnostic biomarker. Compared with 800-nm OCT, it provides superior visualization of the posterior pole in cataractous eyes. (Invest Ophthalmol Vis Sci. 2010;51:5260-5266) DOI:10.1167/iovs.10-5196