期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 120, 期 1, 页码 38-46出版社
WILEY
DOI: 10.1111/j.1600-0404.2008.01118.x
关键词
body mass index; diabetic neuropathy; nerve conduction; quantitative sensory thresholds; sural nerve pathology
资金
- Albert Pahlsson Foundation
- Crafoord Foundation
- Swedish Heart Lung Fund
- Lundstrom Foundation
- Research Funds Malmo University Hospital
- Swedish Diabetes Association
- Thorsten and Elsa Segerfalks Foundation
- Diabetesforeningen i Malmo med omnejd
- Konsul Thure Carlsson Fund for Medical Research
- Region Skane
- Swedish Medical Research Council [0084, 5188]
Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). Subjects with low MNFD (<= 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.
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