期刊
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
卷 55, 期 2, 页码 111-117出版社
AKADEMIAI KIADO ZRT
DOI: 10.1556/AMicr.55.2008.2.3
关键词
Aspergillus nidulans; proteinase; heterotrimeric G proteins; carbon starvation
Extracellular proteinase production induced by carbon starvation was studied in a series of heterotrimeric G protein signaling pathway mutants of Aspergillus nidulans. All the mutants tested - including Delta fadA (G alpha), Delta sfaD (G beta), Delta gpgA (G gamma) and Delta sfgA (regulator of FadA signaling) - showed an elevated proteinase production after glucose depletion. Our results strongly support the view that during growth, FadA/SfaD/GpgA G protein signaling inhibits proteinase production via both Ga and G beta gamma subunits, and all conditions, which are not sufficient to support vegetative growth and, hence, inhibit this type of G protein signaling, elevate extracellular proteinase activities.
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