期刊
INFLAMMATORY BOWEL DISEASES
卷 21, 期 2, 页码 409-418出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MIB.0000000000000236
关键词
inflammatory bowel disease; colitis associated cancer; colorectal cancer; inflammation; cytokines; chemokines
资金
- NCI NIH HHS [T32 CA009035] Funding Source: Medline
- NIDDK NIH HHS [R00 DK088589] Funding Source: Medline
Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal damage due to chronic inflammation. In addition, the perpetual state of inflammation predisposes individuals to the development of colitis-associated cancer. Because of the immense immune cell infiltration into colon, cytokines produced by immune cells are major players in the initiation and progression of IBD and colitis-associated cancer. In this review, we will explore the functions of many key cytokines and their roles in IBD and colitis-associated cancer, as well as their influences on the immune system and stromal cells. Finally, we will briefly discuss current therapies and current clinical trials targeting cytokines in IBD.
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