期刊
INFLAMMATION RESEARCH
卷 64, 期 5, 页码 287-301出版社
SPRINGER BASEL AG
DOI: 10.1007/s00011-015-0813-1
关键词
Nephrotic syndrome; Idiopathic nephrotic syndrome; Animal model; Doxorubicin; Proteinuria
资金
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil)
- FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais, Brazil)
- Grant INCT-MM (Instituto Nacional de Ciencia e Tecnologia-Medicina Molecular: FAPEMIG) [CBB-APQ-00075-09/CNPq 573646/2008-2]
- CAPES fellowship
- CNPq fellowship
- CNPq
Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, generalized edema, and hyperlipidemia. It begins by changes in the glomerular filtration barrier, with increased permeability to plasma proteins. It affects all age groups and can progress to end-stage renal disease. NS pathophysiology is still unknown. However, the critical role of the immune system is well recognized. Animal models are useful tools for the investigation of NS. Among different experimental models proposed in the literature, disease induced by Doxorubicin has been considered helpful to the purpose of many studies. The aim of this review article is to describe the animal model of NS induced by the injection of Doxorubicin in rodents, with emphasis on action of the drug, potential mechanisms of renal injury, as well biochemical, histological, and corporal changes obtained with this model.
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