期刊
INFLAMMATION
卷 39, 期 1, 页码 96-106出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-015-0227-9
关键词
quercetin; hepatitis; inflammation; nuclear factor kappa B; high-mobility group box 1 protein; toll-like receptor
资金
- National Science Foundation of China [81170398]
- National Clinical Key Special Subject of China
The dietary flavonoid quercetin has hepatoprotective effects. We analyzed the effects of quercetin on concanavalin A (ConA)-induced hepatitis in mice and its underlying molecular mechanisms of action. Mice were administered quercetin (50 mg/kg body weight, i.p.) or vehicle 30 min before intravenous administration of ConA. Quercetin pretreatment significantly reduced the ConA-induced elevations in plasma aminotransferase concentrations and liver necrosis, as well as reducing serum concentrations of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interferon-gamma, and interleukin-4. Quercetin pretreatment also reduced expression of high-mobility group box 1 protein (HMGB1) and toll-like receptor (TLR)-2 and TLR-4 messenger RNA (mRNA) and protein in liver tissues. Quercetin pretreatment significantly inhibited degradation of inhibitory kappa B alpha and modulated ConA-induced nuclear translocation in the liver of nuclear factor kappa B (NF-kappa B) p65. These results demonstrate that quercetin protects against ConA-mediated hepatitis in mice by attenuating the HMGB1-TLRs-NF-kappa B signaling pathway.
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