期刊
INFECTION GENETICS AND EVOLUTION
卷 36, 期 -, 页码 462-466出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2015.08.017
关键词
Influenza virus; H5N6; Swine; Reassortment; Public health
资金
- SAMP
- T Innovation Program for the Molecular Ecology of Animal Viruses, CAAS, National Natural Science Foundation of China [81571998]
- Cooperative Project of SAMP
- T from Henan province, China [132106000065]
- Ministry of Science and Technology [2012 ZX10004214]
Novel H5N6 influenza A viruses have infected birds and human beings and caused four human clinical cases in China since 2014. The pig, as a mixing vessel, plays an important role for influenza virus reassortment and transmission. Towards this, routine surveillance for swine influenza in Guangdong province was conducted in 2014. In this study, we reported the biological characterization of two H5N6 influenza viruses isolated from healthy pigs in Guangdong province. Genetic analysis indicates that the two viruses are reassortants of 2.3.4.4 H5N1 and H6N6 avian influenza viruses with a high similarity to duck and human H5N6 influenza viruses isolated from Guangdong province. The data from chicken and mouse experiments show that the viruses are highly pathogenic in chickens and result in a systemic infection, and replicate in the mouse lung accompanying with a clinical inflammatory pathology. The results of the study demonstrate that the two H5N6 influenza viruses isolated from swine are the avian-originated viruses and have not adapted to swine population yet. However, they might keep evolving and pose a potential risk to public health and the continued surveillance of swine influenza should be strengthened. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据