期刊
CANCER MICROENVIRONMENT
卷 3, 期 1, 页码 137-147出版社
SPRINGER
DOI: 10.1007/s12307-010-0037-4
关键词
miRNAs; Cancer metastasis; Invasion; Cancer stem cells and angiogenesis
类别
资金
- The University of Texas M. D. Anderson Research Trust
- The University of Texas System Regents Research Scholar Program
- Ladjevardian Regents Research Scholar Fund
- Anne and Henry Zarrow Foundation
- NIH [1R01CA135444]
Cancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in the circulation; 5) extravasation into distant organs; and 6) colonization and growth of metastatic tumors. microRNAs (miRNAs) play critical roles in this multi-step process, both promoting and suppressing metastasis. This review updates the progress made in understanding the roles of miRNAs for invasion and metastasis during cancer progression. A specific miRNA signature of cancer metastasis is also reviewed.
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