期刊
CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM
卷 8, 期 4, 页码 201-212出版社
SPRINGER
DOI: 10.1007/s12018-010-9078-y
关键词
Bone; Primary cilia; Mechanotransduction; Mechanosensor
资金
- NIH [AR45989, AR45156]
- New York Stem Cell Grant [N06G-210]
Mechanotransduction is a process in which cells sense applied mechanical stimulus and convert these forces into biochemical responses. This process regulates skeletal homeostasis, organization, and development, although the cellular mechanism that is responsible for mechanotransduction in bone is currently unknown. One candidate mechanosensor is the primary cilium, a single immotile organelle that extends from the surface of bone cells. The inhibition of primary cilia formation or associated components leads to reduced expression of mechanosensitive osteogenic genes, impaired osteoblastic differentiation, and skeletal phenotype irregularities. In this review, we discuss growing evidence supporting primary cilia as mediators of mechanically regulated skeletal homeostasis and development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据