期刊
CANCER MICROENVIRONMENT
卷 3, 期 1, 页码 149-166出版社
SPRINGER
DOI: 10.1007/s12307-010-0038-3
关键词
Colon cancer; Stroma; Tumor microenvironment; Tumor infiltrating cells; Extracellular matrix
类别
资金
- NCI NIH HHS [P01 CA077839] Funding Source: Medline
- NIDDK NIH HHS [R37 DK047297, R01 DK062112] Funding Source: Medline
Colorectal cancer is the second leading cause of cancer-related mortality in the United States. Therapeutic developments in the past decade have extended life expectancy in patients with metastatic disease. However, metastatic colorectal cancers remain incurable. Numerous agents that were demonstrated to have significant antitumor activity in experimental models translated into disappointing results in extending patient survival. This has resulted in more attention being focused on the contribution of tumor microenvironment to the progression of a number of solid tumors including colorectal cancer. A more complete understanding of interactions between tumor epithelial cells and their stromal elements will enhance therapeutic options and improve clinical outcome. Here we will review the role of various stromal components in colorectal carcinogenesis and discuss the potential of targeting these components for the development of future therapeutic agents.
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