期刊
THERAPEUTIC DELIVERY
卷 1, 期 6, 页码 849-861出版社
FUTURE SCI LTD
DOI: 10.4155/TDE.10.61
关键词
siRNA; Aptamers; shRNA; Antisense oligonucleotide; SELEX
资金
- Ladies Auxiliary to the Veterans of Foreign Wars Postdoctoral Fellowship
- NIH [1RO1 CA138503-01A1, 1R21DE019953-01]
- Mary Kay Ash Foundation [MKACF 001-09]
The clinical potential of siRNAs for silencing genes critical to disease progression is clear, but a fail-proof method for delivering siRNAs to the cytoplasm of diseased tissues or cells has yet to be identified. A variety of delivery approaches have been explored to directly or indirectly couple siRNAs to delivery vehicles. This review explores the use of synthetic single-stranded DNA and RNA aptamers as a means to deliver siRNAs, shRNAs and antisense oligonucleotides for therapeutic intervention. Topics covered include: the advantages and challenges of using aptamers as delivery tools; current aptamer-mediated siRNA delivery platforms for the treatment of cancer and HIV; and emerging methodologies for the identification of aptamers capable of internalizing into target cell types.
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