期刊
CANCER MICROENVIRONMENT
卷 3, 期 1, 页码 127-135出版社
SPRINGER
DOI: 10.1007/s12307-010-0036-5
关键词
Scirrhous gastric cancer; Fibroblasts.; Stromal cells; Interaction; Microenvironment; Growth factor
类别
Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies.
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