期刊
ACTA HISTOCHEMICA
卷 116, 期 5, 页码 803-809出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.acthis.2014.01.010
关键词
Desmoglein 3; Esophageal squamous cell carcinoma; Prognosis
类别
资金
- National Natural Science Foundation of China [81101613]
- Guangdong Provincial Natural Science Foundation of China [S2011040004363]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20114402120005]
- Natural Science Foundation of China-Guangdong Joint Fund [U0932001]
Desmoglein 3 (DSG3), a transmembrane cadherin of the desmosomal cell-cell adhesion structure, plays vital roles in the maintenance of normal epithelial tissue architecture. Reports implicating a role for DSG3 expression in cancer are few and contradictory. In this study, immunohistochemical staining was employed to investigate DSG3 expression and subcellular localization in esophageal squamous cell carcinoma (ESCC), and to correlate changes with clinical characteristics. Results indicate that in normal squamous cell epithelia, strong DSG3 immunoreactivity was observed in the Stratum spinosum, and localization occurred only at the cell membrane. In ESCC, DSG3 immunoreactivity displayed an abnormal cytoplasmic localization that was correlated with cell differentiation (P = 0.018). Most strikingly, in 74.1% of the tumors, DSG3 expression was up-regulated and correlated with regional lymph node metastasis (P = 0.036). Moreover, in patients without lymph node metastasis, cytoplasmic localization of DSG3 correlated with poor prognosis (P = 0.044). These results suggest that DSG3 is involved in the development of ESCC and imply that DSG3 overexpression is likely to be an essential contributor to the aggressive features of esophageal cancer. (C) 2014 Elsevier GmbH. All rights reserved.
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