期刊
ACTA HISTOCHEMICA
卷 115, 期 4, 页码 349-356出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.acthis.2012.09.007
关键词
Pancreatic cancer stem cell; Panc-1; MDR1; Drug-resistance
类别
资金
- National Natural Science Foundation of China [81001319, 81101677]
- Natural Science Foundation of Jiangsu Province [BK2011487]
- Social Development Foundation of Zhenjiang City [SZC201130128]
- High-Tech of Jiangsu University [11JDG128]
Pancreatic cancer is an aggressive malignant disease. Owing to the lack of early symptoms, accompanied by extensive metastasis and high resistance to chemotherapy, pancreatic adenocarcinoma becomes the fourth leading cause of cancer-related deaths. In this study, we identified a subpopulation of cells isolated from the Panc-1 cell line and named pancreatic cancer stem-like cells. These Panc-1 stem-like cells expressed high levels of CD133/CD44/Oct4/Nestin. Compared to Panc-1 cells, Panc-1 stem-like cells were resistant to gemcitabine and expressed high levels of MDR1; furthermore, Panc-1 stem-like cells have high anti-apoptotic, but weak proliferative potential. These results indicated that Panc-1 stem-like cells, as a novel group, may be a potential major cause of pancreatic cancer multidrug resistance and extensive metastasis. (C) 2012 Elsevier GmbH. All rights reserved.
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