期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 308, 期 8, 页码 E670-E679出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00576.2014
关键词
total hip arthroplasty; muscle atrophy; inflammation; muscle protein metabolism; muscle regeneration
资金
- National Institutes of Health [R01-AR-052293, P30-AG-028718]
- Veterans Affairs Merit Review Award
- UAB Center for Exercise Medicine Core Muscle Research Laboratory
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [T32HD071866] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR052293] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG028718] Funding Source: NIH RePORTER
While elective total hip arthroplasty (THA) for end-stage osteoarthritis (OA) improves pain, mobility function, and quality of life in most cases, a large proportion of patients suffer persistent muscle atrophy, pain, and mobility impairment. Extensive skeletal muscle damage is unavoidable in these surgical procedures, and it stands to reason that poor recovery and long-term mobility impairment among some individuals after THA is linked to failed muscle regeneration and regrowth following surgery and that local muscle inflammation susceptibility (MuIS) is a major contributing factor. Here we present results of two integrated studies. In study 1, we compared muscle inflammation and protein metabolism signaling in elective THA (n = 15) vs. hip fracture/trauma (HFX; n = 11) vs. nonsurgical controls (CON; n = 19). In study 2, we compared two subgroups of THA patients dichotomized into MuIS((+)) (n = 7) or MuIS((-)) (n = 7) based on muscle expression of TNF-like weak inducer of apoptosis (TWEAK) receptor (Fn14). As expected, HFX demonstrated overt systemic and local muscle inflammation and hypermetabolism. By contrast, no systemic inflammation was detected in elective THA patients; however, local muscle inflammation in the perioperative limb was profound in MuIS((+)) and was accompanied by suppressed muscle protein synthesis compared with MuIS((-)). Muscle from the contralateral limb of MuIS((+)) was unaffected, providing evidence of a true inflammation susceptibility localized to the muscle surrounding the hip with end-stage OA. We suggest MuIS status assessed at the time of surgery may be a useful prognostic index for muscle recovery potential and could therefore provide the basis for a personalized approach to postsurgery rehabilitation.
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