期刊
ACTA HISTOCHEMICA
卷 110, 期 6, 页码 451-461出版社
ELSEVIER GMBH
DOI: 10.1016/j.acthis.2007.12.008
关键词
Adrenal gland; Insulin-like growth factors; Steroidogenic acute regulatory protein; Type I insulin-like growth factor receptor; Frog
类别
资金
- Research Fund of Istanbul University [BYPF-7-2006-6/19072006]
The sole structural determinant for the differential ability of the insulin-like growth factors (IGF-I and IGF-II) to induce autophosphorylation of specific insulin receptor (IR) tyrosine residues and activate downstream signaling molecules is the C domain. The IR is structurally related to the type I insulin-like growth factor receptor (IGF-IR). This study aimed to identify the presence of IGF receptors by which the IGF-II C-peptide could mediate its effects in the frog (Rana ridibunda) adrenal glands and to observe whether injection of IGF-II C-peptide affects the function of adrenal steroidogenic cells using light and transmission electron microscopy and by the evaluation of the immunoreactivity of steroidogenic acute regulatory protein (StAR). After IGF-II C-peptide injection, there was a reduction of StAR protein immunoreactivity levels, an accumulation of large Lipid droplets in close contact with each other, and an induction of proliferation of the steroidogenic cells. These results indicate a possible rote of IGF-II C-peptide in steroidogenic cell function and in induction of steroidogenesis. The detection in this study of IGF-I receptor (IGF-IR) immunoreactivity in frog adrenal glands also indicates that the metabolic and mitogenic effects of IGF-II C-peptide in these glands may occur via the IGF-IR. (c) 2008 Elsevier GmbH. All rights reserved.
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