期刊
ACTA HAEMATOLOGICA
卷 120, 期 2, 页码 91-99出版社
KARGER
DOI: 10.1159/000165510
关键词
Antigen-presenting ability; CD33; IL-3; Myeloid dendritic cells; Plasmacytoid dendritic cell leukemia
类别
We report 2 patients with plasmacytoid dendritic cell leukemia (pDCL) expressing CD4, CD56, CD33, CD36, HLA-DR, CD123, CD86 and CD83 in the absence of lineage markers (myeloid, B, T or natural killer cells) except for CD33. Culturing leukemic blasts of both cases with IL-3 for 4 days increased the expression of surface molecules associated with antigen presentation, e. g. CD1a and CD40. Leukemic blasts of both cases possessed a considerable level of antigen-presenting ability to allogeneic lymphocytes in mixed leukocyte cultures. Culturing the blasts with IL-3 for 4 days markedly increased allogeneic antigen presenting ability. Combined with data showing evident graft-versus-leukemia effects without graft-versus-host disease in a cord blood stem cell transplanted pDCL case, leukemic cells in pDCL may act as potent antigen presenting cells in vivo, too. Copyright (C) 2008 S. Karger AG, Basel
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