期刊
ACTA DERMATO-VENEREOLOGICA
卷 94, 期 6, 页码 691-694出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-1824
关键词
psoriasis; weight reduction; comorbidity; cardiovascular
类别
资金
- Cambridge Manufacturing Company Limited
- Michaelsen Foundation
- Aase and Ejnar Danielsen Foundation
- Research Foundation of the Danish Academy of Dermatology
- Danish Agriculture and Food Council
- Jacob Madsen and Olga Madsen Foundation
- Psoriasis Research Foundation
- Medical Research Foundation of the Capital Region of Denmark
- Oak Foundation
Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry, selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, very low density lipoprotein cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by peripheral arterial tonometry remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.
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