期刊
NATURE REVIEWS CANCER
卷 11, 期 2, 页码 111-121出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3002
关键词
-
类别
资金
- US NIH [CA34936, DK069599]
- NCI CCSG [CA16672]
- NCI CPRIT [RP100329, RP110234]
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding beta-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据