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Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

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NATURE REVIEWS CANCER
卷 11, 期 2, 页码 111-121

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NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3002

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  1. US NIH [CA34936, DK069599]
  2. NCI CCSG [CA16672]
  3. NCI CPRIT [RP100329, RP110234]

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Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding beta-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?

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