期刊
ACTA DERMATO-VENEREOLOGICA
卷 92, 期 6, 页码 625-628出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-1453
关键词
regulatory T cells; Foxp3; CD163; macrophages; matrix metalloproteinase-9
类别
资金
- Grants-in-Aid for Scientific Research [23659541] Funding Source: KAKEN
Regulatory T cells (Tregs), identified by the expression of CD4, CD25 and Foxp3, together with immunosuppressive macrophages, such as CD163(+) M2 macrophages, are involved in maintaining peripheral tolerance. The aim of this study was to elucidate the involvement of Tregs and CD163(+) macrophages in invasive and non-invasive extramammary Paget's disease. The presence of CD4(+)CD25(+)Foxp3+ Tregs, CD163(+) M2 macrophages and matrix metalloproteinase-9(+) cells was examined immunohistologically in fixed sections of lesional skin from 10 patients with non-invasive extramammary Paget's disease and 7 patients with invasive extramammary Paget's disease. Fewer CD4(+)CD25(+)Foxp3(+) Tregs were observed in non-invasive extramammary Paget's disease than in invasive extramammary Paget's disease. In contrast, higher numbers of CD163(+) macrophages and metalloproteinase-9(+) cells were detected only in invasive extramammary Paget's disease. These findings suggest that the induction of immunosuppressive cells in extramammary Paget's disease differs according to the tumour stage.
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