期刊
ACTA DERMATO-VENEREOLOGICA
卷 92, 期 5, 页码 521-528出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-1350
关键词
psoriasis; pruritus; C-fibre; nerve growth factor; semaphorin-3A; neuropilin-1; NGF; Sema3A
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [19591320, 21591471]
- National Project on Protein Structural and Functional Analyses of MEXT [07085023]
- Grants-in-Aid for Scientific Research [21591471, 22650084, 22591247, 19591320] Funding Source: KAKEN
Pruritus is a common symptom of psoriasis, which affects quality of life. This symptom accompanies the hyper-innervation of sensory C-fibres in psoriatic lesions. Two extracellular molecules, nerve growth factor (NGF) and semaphorin-3A, regulate C-fibre extension. In this study, the expression levels of these 2 molecules in biopsy specimens from psoriatic and healthy skin were quantified by immunohistochemistry and quantitative reverse-transcription PCR. Semaphorin-3A expression was lower in the psoriatic samples compared with the healthy samples, whereas NGF was higher. C-fibre innervation in the epidermis was also increased in psoriatic skin. Semaphorin-3A mRNA expression was negatively correlated with itch intensity and severity of psoriasis. We propose that decreased semaphorin-3A and increased NGF expression levels may trigger the outgrowth of C-fibres, leading to pruritus.
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