期刊
NATURE REVIEWS CANCER
卷 11, 期 2, 页码 96-110出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2998
关键词
-
类别
资金
- National Cancer Institute [CA09717, CA132840]
- National Institute of Environmental Health Sciences [P30ES007784]
- NIH Cancer Center (University of Texas MD Anderson Cancer Center, USA) [P30-CA016672]
There are 15 different DNA polymerases encoded in mammalian genomes, which are specialized for replication, repair or the tolerance of DNA damage. New evidence is emerging for lesion-specific and tissue-specific functions of DNA polymerases. Many point mutations that occur in cancer cells arise from the error-generating activities of DNA polymerases. However, the ability of some of these enzymes to bypass DNA damage may actually defend against chromosome instability in cells, and at least one DNA polymerase, Pol zeta, is a suppressor of spontaneous tumorigenesis. Because DNA polymerases can help cancer cells tolerate DNA damage, some of these enzymes might be viable targets for therapeutic strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据