期刊
JOURNAL OF PHARMACEUTICAL ANALYSIS
卷 1, 期 1, 页码 32-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S2095-1779(11)70006-5
关键词
time-resolved chemiluminescence; artificial neural network; captopril; hydrochlorothiazide
资金
- National Natural Science Foundation of China [20675063]
The combined use of chemometrics and chemiluminescence (CL) measurements, with the aid of the stoppedflow mixing technique, developed a simple time-resolved CL method for the simultaneous determination of captopril (CPL) and hydrochlorothiazide (HCT). The stopped-flow technique in a continuous-flow system was employed in this work in order to emphasize the kinetic differences between the two analytes in cerium (IV)-rhodamine 60 CL system. After the flow was stopped, an initial rise of CL signal was observed for HCT standards, while a direct decay of CL signal was obtained for CPL standards. The mixed CL signal was monitored and recorded on the whole process of continuousflow/stopped-flow, and the obtained data were processed by the chemometric approach of artificial neural network. The relative prediction error (RPE) of CPL and HCT was 5.9% and 8.7%, respectively. The recoveries of CPL and HCT in tablets were found to fall in the range between 95% and 106%. The proposed method was successfully applied to the simultaneous determination of CPL and HCT in a compound pharmaceutical formulation.
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