期刊
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
卷 64, 期 -, 页码 318-322出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1744309108007197
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资金
- NATIONAL EYE INSTITUTE [PN2EY018230] Funding Source: NIH RePORTER
- NEI NIH HHS [PN2 EY018230, PN2EY018230] Funding Source: Medline
Hepatitis E virus (HEV) accounts for the majority of enterically transmitted hepatitis infections worldwide. Currently, there is no specific treatment for or vaccine against HEV. The major structural protein is derived from open reading frame ( ORF) 2 of the viral genome. A potential oral vaccine is provided by the virus-like particles formed by a protein construct of partial ORF3 protein ( residue 70-123) fused to the N-terminus of the ORF2 protein ( residues 112 608). Single crystals obtained by the hanging-drop vapour-diffusion method at 293 K diffract X-rays to 8.3 angstrom resolution. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 337, b = 343, c = 346 angstrom, alpha = beta = gamma = 90 degrees, and contain one particle per asymmetric unit.
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