期刊
FEMS MICROBIOLOGY REVIEWS
卷 35, 期 2, 页码 247-274出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2010.00247.x
关键词
quorum sensing; quinolone; quinoline; Pseudomonas; Burkholderia; virulence
类别
资金
- Biological and Biotechnological Sciences Research Council UK [BBF0143921]
- European Union [MST-CT-2005-020278, HEALTH-F3-2009-2009-223670]
- Biotechnology and Biological Sciences Research Council [BB/F014392/1] Funding Source: researchfish
- BBSRC [BB/F014392/1] Funding Source: UKRI
Since quinine was first isolated, animals, plants and microorganisms producing a wide variety of quinolone compounds have been discovered, several of which possess medicinally interesting properties ranging from antiallergenic and anticancer to antimicrobial activities. Over the years, these have served in the development of many synthetic drugs, including the successful fluoroquinolone antibiotics. Pseudomonas aeruginosa and related bacteria produce a number of 2-alkyl-4(1H)-quinolones, some of which exhibit antimicrobial activity. However, quinolones such as the Pseudomonas quinolone signal and 2-heptyl-4-hydroxyquinoline act as quorum-sensing signal molecules, controlling the expression of many virulence genes as a function of cell population density. Here, we review selectively this extensive family of bicyclic compounds, from natural and synthetic antimicrobials to signalling molecules, with a special emphasis on the biology of P. aeruginosa. In particular, we review their nomenclature and biochemistry, their multiple properties as membrane-interacting compounds, inhibitors of the cytochrome bc(1) complex and iron chelators, as well as the regulation of their biosynthesis and their integration into the intricate quorum-sensing regulatory networks governing virulence and secondary metabolite gene expression.
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