期刊
EMERGING INFECTIOUS DISEASES
卷 17, 期 3, 页码 412-418出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1703.100979
关键词
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资金
- Dutch Food and Consumer Product Safety Authority
- European Commission [SP22-CT-2004-502571]
- Directorate General for Health and Consumer Affairs [2003213]
International foodborne norovirus outbreaks can be difficult to recognize when using standard outbreak investigation methods. In a novel approach, we provide step-wise selection criteria to identify clusters of outbreaks that may involve an internationally distributed common foodborne source. After computerized linking of epidemiologic data to aligned sequences, we retrospectively identified 100 individually reported outbreaks that potentially represented 14 international common source events in Europe during 1999-2008. Analysis of capsid sequences of outbreak strains (n = 1,456), showed that approximate to 7% of outbreaks reported to the Food-Borne Viruses in Europe database were part of an international event (range 2%-9%), compared with 0.4% identified through standard epidemiologic investigations. Our findings point to a critical gap in surveillance and suggest that international collaboration could have increased the number of recognized international foodborne outbreaks. Real-time exchange of combined epidemiologic and molecular data is needed to validate our findings through timely trace-backs of clustered outbreaks.
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