期刊
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
卷 54, 期 14, 页码 3685-3696出版社
AMER CHEMICAL SOC
DOI: 10.1021/ie5046445
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Aspirin, which is used as a pain killer and is recommended to cure diseases such as arthritis, was precipitated using the gas-antisolvent (GAS) process. The objective of this study was to investigate the effects of four operating parametersnamely, antisolvent addition, process temperature, solute concentration, and solvent type (methanol and acetone)on the final product particle size distribution, morphology, and crystallinity. In accordance to particle size analysis and scanning electron microscopy (SEM), it was observed that the increment of antisolvent addition rate reduced the mean size of precipitated particles and the size distributions became narrower. Furthermore, the process temperature and the solute concentration had a reverse effect on the precipitated aspirin particle size. The crystallized particles had a mean size between 48 mu m and 124 mu m. In contrast, particles precipitated from methanol solution had smaller mean size than from acetone. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) showed that particles produced from acetone had more crystalline structure in comparison with the samples produced from methanol and also the unprocessed purchased aspirin. This can be explained through reduced involvement of methanol into the crystalline structure. The results proved the capability of GAS process for the production of aspirin for the therapeutic applications.
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