期刊
NATURE REVIEWS CANCER
卷 11, 期 3, 页码 218-U88出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3006
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资金
- Univeriste Paris
- Centre National de la Recherche Scientifique (CNRS)
- US National Institutes of Health [R01-CA120288, P30-CA138292]
The majority of human cells do not multiply continuously but are quiescent or slow-replicating and devote a large part of their energy to transcription. When DNA damage in the transcribed strand of an active gene is bypassed by a RNA polymerase, they can miscode at the damaged site and produce mutant transcripts. This process is known as transcriptional mutagenesis and, as discussed in this Perspective, could lead to the production of mutant proteins and might therefore be important in tumour development.
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