期刊
NATURE REVIEWS IMMUNOLOGY
卷 11, 期 4, 页码 289-295出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2959
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资金
- British Biotechnology and Biological Sciences Research Council
- Wellcome Trust
Can the immune system be reactivated continuously throughout the lifetime of an organism or is there a finite point at which repeated antigenic challenge leads to the loss of lymphocyte function or the cells themselves or both? Replicative senescence and exhaustion are processes that control T cell proliferative activity and function; however, there is considerable confusion over the relationship between these two intrinsic cellular control mechanisms. In this Opinion article, we compare the molecular regulation of senescence and exhaustion in T cells. Available data suggest that both processes are regulated independently of each other and that it may be safer to block exhaustion than senescence to enhance immunity.
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