期刊
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
卷 67, 期 -, 页码 91-96出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S0907444910050201
关键词
PduT; Citrobacter freundii; propanediol metabolism; 4Fe-4S cluster-binding site
资金
- Biotechnology and Biology Research Council (BBSRC)
- Higher Education Council of England (HEFCE)
- Queen Mary University of London
- Biotechnology and Biological Sciences Research Council [BB/H013180/1, BB/E010563/1] Funding Source: researchfish
- BBSRC [BB/H013180/1, BB/E010563/1] Funding Source: UKRI
Propanediol metabolism in Citrobacter freundii occurs within a metabolosome, a subcellular proteinaceous bacterial microcompartment. The propanediol-utilization (Pdu) microcompartment shell is constructed from thousands of hexagonal-shaped protein complexes made from seven different types of protein subunit. Here, the structure of the bacterial microcompartment protein PduT, which has a tandem structural repeat within the subunit and forms trimers with pseudo-hexagonal symmetry, is reported. This trimeric assembly forms a flat approximately hexagonally shaped disc with a central pore that is suitable for a 4Fe-4S cluster. The essentially cubic shaped 4Fe-4S cluster conforms to the threefold symmetry of the trimer with one free iron, the role of which could be to supply electrons to an associated microcompartment enzyme, PduS.
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