期刊
ACTA CIRURGICA BRASILEIRA
卷 27, 期 3, 页码 201-209出版社
ACTA CIRURGICA BRASILEIRA
DOI: 10.1590/S0102-86502012000300001
关键词
Mesenchymal Stem Cells; Platelet-Rich Plasma; Tissue Therapy; Skull; Mice
类别
资金
- FAPEMIG
- CAPES
- CNPq
PURPOSE: To evaluate the effects of mesenchymal stem cells (MSC) from eight mice C57BL/6 gfp+ bone marrows expanded in cultures associated with platelets rich plasma (PRP) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice C57BL/6. METHODS: The animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. Control group did not receive treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL associated with 50.0 mu L of plasma gel containing 1.0 x 10(9) autologous platelets within the defect. RESULTS: In the treated group was observed process of angiogenesis and bone repair better than control group. CONCLUSION: Mesenchymal stem cells derived from bone marrow of C57BL/6 gfp(+) mice associated with PRP gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair. Key words: Mesenchymal Stem Cells. Platelet-Rich Plasma. Tissue Therapy. Skull. Mice.
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