期刊
NATURE REVIEWS CANCER
卷 11, 期 5, 页码 317-323出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3051
关键词
-
类别
资金
- American Cancer Society New England-SpinOdyssey Postdoctoral Fellowship
- US National Cancer Institute (NCI) [R01 CA093665]
Adherens junctions, which are intercellular adhesive complexes that are crucial for maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour progression. However, the role of desmosomes - adhesion complexes that are related to adherens junctions - in carcinogenesis has remained elusive. Recent studies using mouse genetic approaches have uncovered a role for desmosomes in tumour suppression, demonstrating that desmosome downregulation occurs before that of adherens junctions to drive tumour development and early invasion, suggesting a two-step model of adhesion dysfunction in cancer progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据