期刊
ACTA CARDIOLOGICA
卷 63, 期 4, 页码 501-506出版社
TAYLOR & FRANCIS LTD
DOI: 10.2143/AC.63.4.2033050
关键词
carbohydrate antigen 125; B-type natriuretic peptide; heart failure; left ventricular ejection fraction
Objective - The objective was to study the association between B-type natriuretic peptide (BNP) and tumour markers and heart failure (HF) to evaluate the value of BNP and carbohydrate antigen 125 (CAI 25) in HF patients. Design and setting - A university hospital-based cross-over study of 285 subjects (157 men and 128 women) in HF, chronic obstructive pulmonary disease (COPD), mild-mid pulmonary hypertension patients and control subjects. Results - CAI 25 and BNP were significantly higher in the HF group than in the non-HF group and in severe HF than in mild HF (P < 0.01). No changes were observed in other tumour markers. CA 125 and BNP decreased obviously after clinical improvement by aggressive treatment (P < 0.01). Left ventricular ejection fraction correlated positively with CA 125 (r = 0.789, P < 0.01) and BNP (r = 0.730, P < 0.01) in left heart failure patients, but not in other patients. BNP and CAI 25 had better accuracy and positive predictive value in diagnosing HF from the characteristic receiver-operator curve. Conclusions - CAI 25 and BNP are markedly elevated in heart failure and closely reflect heart function. They are better markers in evaluating the efficiency of short-term therapy. Detecting BNP combined with CA125 may be more valuable than only detecting BNP or CA125 for diagnosing HF and evaluating the efficiency of treatment.
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