期刊
NATURE REVIEWS CANCER
卷 11, 期 5, 页码 352-363出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3053
关键词
-
类别
资金
- Center for Cancer Research, US National Cancer Institute
- Center of Excellence from the US Department of Defense [W81XWH-062-0033]
The incidence of metastasis to the brain is apparently rising in cancer patients and threatens to limit the gains that have been made by new systemic treatments. The brain is considered a 'sanctuary site' as the blood-tumour barrier limits the ability of drugs to enter and kill tumour cells. Translational research examining metastasis to the brain needs to be multi-disciplinary, marrying advanced chemistry, blood-brain barrier pharmacokinetics, neurocognitive testing and radiation biology with metastasis biology, to develop and implement new clinical trial designs. Advances in the chemoprevention of brain metastases, the validation of tumour radiation sensitizers and the amelioration of cognitive deficits caused by whole-brain radiation therapy are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据