期刊
APPETITE
卷 51, 期 1, 页码 34-41出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.appet.2007.09.016
关键词
food craving; smoking; substance addiction; brain stimulation; transcranial direct current stimulation; brain polarization
资金
- NCRR NIH HHS [K24 RR018875] Funding Source: Medline
- NHLBI NIH HHS [K30 HL004095, NIH K30 HL04095] Funding Source: Medline
We aimed to assess whether modulation of the dorsolateral prefrontal cortex (DLFPC) with noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies food craving in healthy subjects. We performed a randomized sham-controlled cross-over study in which 23 subjects received sham and active tDCS (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were exposed to food and also watched a movie of food associated with strong craving. Desire for food consumption was evaluated by visual analogue scales (VAS) and food consumption before and after treatment. In addition we measured visual attention to food using an eye tracking system. Craving for viewed foods as indexed by VAS was reduced by anode right/cathode left tDCS. After sham stimulation, exposure to real food or food-related movie increased craving; whereas after anode left/cathode right tDCS, the food-related stimuli did not increase craving levels, as revealed by the VAS scale. Moreover, compared with sham stimulation, subjects fixated food-related pictures less frequently after anode right/cathode left OCS and consumed less food after both active stimulation conditions. These changes were not related to mood changes after any type of tDCS treatment. The effects of OCS on food craving might be related to a modulation of neural circuits associated with reward and decision-making. (C) 2007 Elsevier Ltd. All rights reserved.
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