期刊
ACTA BIOMATERIALIA
卷 10, 期 6, 页码 2727-2738出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.02.030
关键词
Cardiac patch; Electrospun nanofibers; Mesenchymal stem cells; Myocardial infarction; Improvement of cardiac function
资金
- Changjiang Scholars Program of the Ministry of Education of China [101-07-005707]
- NRF-Technion Grant (WBS) [R-398-001-065-592]
- National Natural Science Foundation of China [30971674, 81270200]
- Science and Technology Commission of Shanghai Municipality [11540702500]
Myocardial infarction (MI) leads to the loss of cardiomyocytes, followed by left ventricular (LV) remodeling and cardiac dysfunction. The authors hypothesize that an elastic, biodegradable nanofibrous cardiac patch loaded with mesenchymal stem cells (MSC) could restrain LV remodeling and improve cardiac function after MI. Poly(epsilon-caprolactone)/gelatin (PG) nanofibers were fabricated by electrospinning, and the nanofibers displayed a porous and uniform nanofibrous structure with a diameter of 244 +/- 51 nm. An MI model was established by ligation of the left anterior descending coronary artery of female Sprague-Dawley rats. The PG nanofibrous patch seeded with MSC, isolated from rat bone marrow, was implanted on the epicardium of the infarcted region of the LV wall of the heart. After transplantation, the PG-cell patch restricted the expansion of the LV wall effectively and reduced the scar size, and the density of the microvessels increased. Cells within the patch were able to migrate towards the scar tissue, and promoted new blood vessel formation at the infarct site. Angiogenesis and the cardiac functions improved significantly after 4 weeks of implantation. The MSC-seeded PG nanofibrous patches are demonstrated to provide sufficient mechanical support, to induce angiogenesis and to accelerate cardiac repair in a rat model of MI. The study highlights the positive impact of implantation of an MSC-seeded PG nanofibrous patch as a novel constituent for MI repair. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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