期刊
ACTA BIOMATERIALIA
卷 10, 期 4, 页码 1502-1514出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.09.008
关键词
Fibrin; Biomaterial design; Fibrin glue; Wound repair; Tissue engineering
资金
- NIBIB NIH HHS [R21 EB013743, R01 EB011566] Funding Source: Medline
Fibrinogen is one of the primary components of the coagulation cascade and rapidly forms an insoluble matrix following tissue injury. In addition to its important role in hemostasis, fibrin acts as a scaffold for tissue repair and provides important cues for directing cell phenotype following injury. Because of these properties and the ease of polymerization of the material, fibrin has been widely utilized as a biomaterial for over a century. Modifying the macroscopic properties of fibrin, such as elasticity and porosity, has been somewhat elusive until recently, yet with a molecular-level rational design approach it can now be somewhat easily modified through alterations of molecular interactions key to the protein's polymerization process. This review outlines the biochemistry of fibrin and discusses methods for modification of molecular interactions and their application to fibrin based biomaterials. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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