期刊
ACTA BIOMATERIALIA
卷 10, 期 10, 页码 4296-4303出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.06.024
关键词
Anti-fouling; 3-D zwitterionic materials; rhBMP-2 delivery; Bone tissue engineering
资金
- National Institutes of Health [R01AR055615]
- United States National Center for Research Resources Grant [S10RR027082]
Zwitterions are well known for their anti-biofouling properties. Past investigations of zwitterionic materials for biomedical uses have been centered on exploiting their ability to inhibit non-specific adsorption of proteins. Here, we report that zwitterionic motifs, when presented in three dimensions (e.g. in crosslinked hydrogels), could effectively sequester osteogenic bone morphogenetic protein-2 (rhBMP-2). The ionic interactions between rhBMP-2 and the 3-D zwitterionic network enabled dynamic sequestering and sustained release of the protein with preserved bioactivity. We further demonstrated that the zwitterionic hydrogel confers high-efficiency in vivo local delivery of rhBMP-2. It can template the functional healing of critical-size femoral segmental defects in rats with rhBMP-2 at a loading dose substantially lower than those required for current natural or synthetic polymeric carriers. These findings reveal a novel function of zwitterionic materials beyond their commonly perceived anti-biofouling property, and may establish 3-D zwitterionic matrices as novel high-efficiency vehicles for protein/ionic drug therapeutic delivery. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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