Phage-based nanomaterials for biomedical applications

Recent advances in nanotechnology enable us to manipulate and produce materials with molecular level control. In the newly emerging field of bionanomedicine, it is essential to precisely control the physical, chemical and biological properties of materials. Among other biological building blocks, viruses are a promising nanomaterial that can be functionalized with great precision. Since the production of viral particles is directed by the genetic information encapsulated in their protein shells, the viral particles create precisely defined sizes and shapes. In addition, the composition and surface properties of the particles can be controlled through genetic engineering and chemical modification. In this manuscript, we review the advances of virus-based nanomaterials for biomedical applications in three different areas: phage therapy, drug delivery and tissue engineering. By exploiting and manipulating the original functions of viruses, viral particles hold great possibilities in these biomedical applications to improve human health. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.