期刊
ACTA BIOMATERIALIA
卷 10, 期 12, 页码 5116-5127出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.08.021
关键词
Layer-by-layer; Nanoarchitecture; Doxorubicin; Mitoxantrone; Liposome
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012R1A2A2A02044997, 2012R1A1A1039059]
- National Research Foundation of Korea [22A20130000184, 2012R1A2A2A02044997] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Layer-by-layer (LbL)-engineered nanoparticles (NPs) are a promising group of therapeutic carriers used in an increasing number of biomedical applications. The present study uses a controlled LbL process to create a multidrug-loaded nanoplatform capable of promoting blood circulation time, biodistribution profile and controlling drug release in the dynamic systemic environment. LbL assembly is achieved by sequential deposition of poly-c-lysine (PLL) and poly(ethylene glycol)block-poly(L-aspartic acid) (PEG-b-PLD) on liposomal nanoparticles (LbL-LNPs). This generates spherical and stable multilayered NP similar to 240 nm in size, enabling effective systemic administration. The numerous functional groups and compartments in the polyelectrolyte shell and core facilitate loading with doxorubicin and mitoxantrone. The nanoarchitecture effectively controls burst release, providing different release kinetics for each drug. LbL-LNPs are pH-sensitive, indicating that intracellular drug release can be increased by the acidic milieu of cancer cells. We further demonstrate that the LbL nanoarchitecture significantly reduces the elimination rates of both drugs tested and markedly extends their systemic circulation times, paving the way for efficacious tumor drug delivery. Because this delivery system accommodates multiple drugs, improves drug half-life and diminishes burst release, it provides an exciting platform with remarkable potential for combination therapeutics in cancer therapy. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd . All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据