期刊
ACTA BIOMATERIALIA
卷 9, 期 6, 页码 6885-6897出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.02.009
关键词
Vascular scaffold; Electrospinning; Biodegradable; Crosslinking; Gamma irradiation
资金
- Queensland State Government under the National and International Research Alliance Scheme
- Australian Research Council (ARC) [LE0775684, LE0668517, DP0987407]
The growth of suitable tissue to replace natural blood vessels requires a degradable scaffold material that is processable into porous structures with appropriate mechanical and cell growth properties. This study investigates the fabrication of degradable, crosslinkable prepolymers of L-lactide-co-trimethylene carbonate into porous scaffolds by electrospinning. After crosslinking by gamma-radiation, dimensionally stable scaffolds were obtained with up to 56% trimethylene carbonate incorporation. The fibrous mats showed Young's moduli closely matching human arteries (0.4-0.8 MPa). Repeated cyclic extension yielded negligible change in mechanical properties, demonstrating the potential for use under dynamic physiological conditions. The scaffolds remained elastic and resilient at 30% strain after 84 days of degradation in phosphate buffer, while the modulus and ultimate stress and strain progressively decreased. The electrospun mats are mechanically superior to solid films of the same materials. In vitro, human mesenchymal stem cells adhered to and readily proliferated on the three-dimensional fiber network, demonstrating that these polymers may find use in growing artificial blood vessels in vivo. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据