期刊
ACTA BIOMATERIALIA
卷 9, 期 9, 页码 8354-8364出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.06.013
关键词
Bone tissue engineering; Composite materials; Electrospinning; Hydroxyapatite; Amphiphilic polymer
资金
- National Institutes of Health [R01AR055615]
- Department of Defense Congressionally Directed Medical Research Programs [W81XWH-10-0574]
- National Center for Research Resources Grant [S10RR021043]
Electrospun polymer/hydroxyapatite (HA) composites combining biodegradability with osteoconductivity are attractive for skeletal tissue engineering applications. However, most biodegradable polymers such as poly(lactic acid) (PLA) are hydrophobic and do not blend with adequate interfacial adhesion with HA, compromising the structural homogeneity, mechanical integrity and biological performance of the composite. To overcome this challenge, we combined a hydrophilic polyethylene glycol (PEG) block with poly(D,L-lactic acid) to improve the adhesion of the degradable polymer with HA. The amphiphilic triblock copolymer PLA-PEG-PLA (PELA) improved the stability of HA-PELA suspension at 25 wt.% HA content, which was readily electrospun into HA-PELA composite scaffolds with uniform fiber dimensions. HA-PELA was highly extensible (failure strain >200% vs. <40% for HA-PLA), superhydrophilic (similar to 0 degrees water contact angle vs. >100 degrees for HA-PLA), and exhibited an 8-fold storage modulus increase (unlike deterioration for HA-PLA) upon hydration, owing to the favorable interaction between HA and PEG. HA-PELA also better promoted osteochondral lineage commitment of bone marrow stromal cells in unstimulated culture and supported far more potent osteogenic gene expression upon induction than HA-PLA. We demonstrate that the chemical incorporation of PEG is an effective strategy to improve the performance of degradable polymer/HA composites for bone tissue engineering applications. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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