期刊
ACTA BIOMATERIALIA
卷 9, 期 10, 页码 8475-8487出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2012.10.001
关键词
Mg-10Dy alloy; In vitro corrosion; Element distribution; Cytocompatibility
资金
- CSC-Helmholtz scholarship
The present work investigates the corrosion behaviour, the element distribution in the corrosion layer and the cytocompatibility of alloy Mg-10Dy. The corrosion experiments were performed in a cell culture medium (CCM) under cell culture conditions close to the in vivo environment. The element distribution on the surface as well as in cross-sections of the corrosion layer was investigated using scanning electron microscopy, energy-dispersive X-ray analysis, X-ray photoelectron spectroscopy and X-ray diffraction. The cytocompatibility of alloy Mg-10Dy with primary human osteoblasts was evaluated by MIT, cell adhesion and live/dead staining tests. The results show that the corrosion layer was enriched in Dy, while the P and Ca content gradually decreased from the surface to the bottom of the corrosion layer. In addition, large amounts of MgCO3-3H(2)O formed in the corrosion layer after 28 days immersion. Both extracts and the Dy-enriched corrosion layer of alloy Mg-10Dy showed no cytotoxicity to primary human osteoblasts. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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