期刊
ACTA BIOMATERIALIA
卷 8, 期 2, 页码 886-896出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.10.018
关键词
Copper; Corrosion; Metal ion release; Biocompatibility; In vitro test
资金
- National Basic Research Program of China (973 Program) [2012CB619102]
- National High Technology Research and Development Program of China (863 Program) [2011AA030101, 2011AA030103]
- Fundamental Research Funds for the Central Universities [HEUCFZ1017]
- National Natural Science Foundation of China [51041004]
- Natural Science Foundation of Heilongjiang Province [ZD201012]
To solve the main problems of existing coarse grained copper (CG Cu) intrauterine devices (IUD)-namely burst release and a low transfer efficiency of the cupric ions during usage-ultra-fine grained copper (UFG Cu) and single crystal copper (SC Cu) have been investigated as potential substitutes. Their corrosion properties with CG Cu as a control have been studied in simulated uterine fluid (SUF) under different conditions using electrochemical measurement methods. Long-term immersion of UFG Cu, SC Cu and CG Cu samples in SUF at 37 degrees C have been studied for 300 days. A lower copper ion burst release and a higher efficiency release of cupric ions were observed for UFG Cu and SC Cu compared with CG Cu in the first month of immersion and 2 months later. The respective corrosion mechanisms for UFG Cu, SC Cu and CG Cu in SUF are proposed. In vitro biocompatibility tests show a better cellular response to UFG Cu and SC Cu than CG Cu. In terms of instantaneous corrosion behavior, long-term corrosion performance and in vitro biocompatibility, the three pure copper materials follow the order: UFG Cu > SC Cu > CG Cu, which indicates that UFG Cu could be the most suitable candidate material for intrauterine devices. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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