期刊
ACTA BIOMATERIALIA
卷 8, 期 12, 页码 4380-4388出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2012.08.014
关键词
Drug delivery; LbL films; Star polymer; Controlled release; Insulin
资金
- National Natural Science Foundation of China [20704026, 51073102]
- Fok Ying Tung Education Foundation [122034]
- Program for New Century Excellent Talents in University [NCET-10-0592]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
- Fundamental Research Funds for the Central Universities [2010SCU22001, 2011SCU04A04]
- Science & Technology Foundation for Youths of Sichuan Province [2012JQ0009]
- Natural Science Foundation of Jiangsu Province [BK2010248, BK2011340]
Insulin, glucose oxidase and positively charged star polymers were incorporated into multilayer films by the layer-by-layer (LbL) assembly method. It is interesting to find that the arrangement sequence of the three components could significantly affect the glucose-responsive controlled release behaviors. The insulin release in vitro could be tuned to linear release and obtain desired on-off' sensitivity in response to stepwise glucose challenge, just by rearranging the assembly sequence of LbL building blocks. Further, the controlled release of insulin in vivo, as well as the hypoglycemic effect, could be obviously prolonged from 17 days to 36 days by this simple strategy without changing the dosage of all the LbL components. In addition to provide a potential glucose-responsive delivery system for insulin, the strategy described in this paper could be valuable for various drug-incorporated LbL systems with three or more components. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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