期刊
ACTA BIOMATERIALIA
卷 7, 期 2, 页码 666-674出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.09.030
关键词
Hyaluronic acid; Hydrogel; Dexamethasone; Drug delivery; Rheumatoid arthritis
资金
- Ministry of Education, Science and Technology [2009-0081871]
- Ministry of Health & Welfare, Republic of Korea [A084132, A080711]
- Korea Health Promotion Institute [A084132] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과C6A2006, 2010-50196] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular cartilage destruction. In this work, injectable tyramine modified hyaluronic acid (HA-Tyr) hydrogels were developed for the treatment of RA. HA-Tyr conjugate was synthesized by amide bond formation between carboxyl groups of HA and amine groups of tyramine. Then, HA-Tyr hydrogels were prepared by radical crosslinking reaction using H2O2 and horse-radish peroxidase. Intra-articular injection of HA-Tyr hydrogels encapsulating dexamethasone (DMT) as a model drug resulted in successful treatment of RA with reduced interlukine-6, prostaglandin E2 and four types of cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin and eosin (H&E) staining also confirmed the therapeutic effect of injectable HA-Tyr hydrogels with DMT. Taken together, the injectable HA-Tyr hydrogels were thought suitable to be developed as a therapeutically effective drug carrier for the treatment of RA. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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