期刊
ACTA BIOMATERIALIA
卷 7, 期 3, 页码 1327-1338出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.10.012
关键词
Quantum dots; Manganese-doped ZnS; Luminescence; Folate; Targeting
资金
- French Embassy in Poland
- French Ligue Nationale contre le Cancer, Comites Lorrains
- Poznan University of Medical Sciences [501-02-03314429-03439-50478]
This work presents a novel approach to producing water soluble manganese-doped core/shell ZnS/ZnS quantum dots (ZnS:Mn/ZnS). The Mn-doped ZnS core was prepared through a nucleation doping strategy and a ZnS shell was grown on ZnS:Mn d-dots by decomposition of Zn2+-3-mercaptopropionic acid (MPA) complexes at 100 degrees C. It was found that the Mn2+ T-4(1) -> (6)A(1) fluorescence emission at similar to 590 nm significantly increased after growth of the shell when the Mn2+ doping content was 4.0 at.%. A photoluminescence quantum yield of similar to 22% was obtained for core/shell nanocrystals. The nanoparticles were structurally and compositionally characterized by transmission electron microscopy. X-ray diffraction, X-ray photoelectron spectroscopy, and dynamic light scattering. The surface MPA molecules favor the dispersion of ZnS:Mn/ZnS QDs in aqueous media and make possible conjugation with targeting folic acid molecules. The folate receptor-mediated delivery of folic acid-conjugated ZnS:Mn/ZnS QDs was demonstrated using confocal microscopy with biphotonic excitation. Bare and folate-conjugated QDs exhibit only weak cytotoxicity towards folate receptor-positive T47D cancer cells and MCF-7 cells, used as a reference, at high concentrations (mmolar range) after 72 h incubation. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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