期刊
ACTA BIOMATERIALIA
卷 7, 期 3, 页码 1166-1172出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.09.041
关键词
Biomaterials; Chitin; Ionic liquids; Supercritical drying; Biomedical applications
资金
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BPD/45307/2008, SFRH/BDP/34994/2007]
- FCT [PTDC/QUI/68804/2006]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI/68804/2006, SFRH/BPD/45307/2008, SFRH/BD/132665/2017] Funding Source: FCT
The application of green chemistry principles in the processing of materials for advanced technologies is a steadily increasing field of research. In this work porous chitin-based materials were developed by combining the processing of chitin using ionic liquids (ILs) as a green solvent together with the use of supercritical fluid technology (SCF) as clean technology. Chitin was dissolved in 1-butyl-3-imidazolium acetate, followed by regeneration of the polymer in ethanol in specific moulds. The IL was removed using Soxhlet extraction and successive steps of extraction with SCF using carbon dioxide/ethanol ratios of 50/50 and 70/30. The developed porous chitin-based structures (ChIL) can be classified as mesoporous materials, with very low density and high porosity. The cytotoxicity of ChIL extracts was investigated using L929 fibroblast-like cells, and the results demonstrated that the produced materials have extremely low cytotoxicity levels. Therefore, the findings suggest that the porous chitin structures may be potential candidates for a number of biomedical applications, including tissue engineering. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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