期刊
ACTA BIOMATERIALIA
卷 7, 期 5, 页码 2337-2344出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.01.006
关键词
Immunotoxicity; Implant; Macrophage; Titanium; Live cell migration
资金
- Pioneer Research Center Program [2010-0002178]
- Basic Science Research Programs [2010-0016245, 2010-0003359]
- Ministry of Education, Science and Technology (MEST) in South Korea
The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and orthopedic applications. However, it has been unclear whether implanted surface nanostructures can inhibit or aggrevate inflammatory responses. Herein, macrophage activation, as evidence of migration, on transparent flat and nanostructured titanium correlated with pro-inflammatory protein synthesis and cytokine release. Through the real-time monitoring of initial cytoskeleton variations, this study identified that macrophage movement was restricted on nanostructured titanium compared to flat titanium surfaces. Furthermore, nanostructured titanium elicited secretion of fewer pro-inflammatory enzyme molecules and cytokines, as well as reduced nitric oxide production. All results collectively indicated that initial macrophage activation can be mitigated by nanoscale surface topography alone, without modification of surface chemistry or stiffness. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd All rights reserved
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