期刊
ACTA BIOMATERIALIA
卷 7, 期 2, 页码 821-828出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.08.023
关键词
Pickering emulsion; Poly(L-lactide-co-epsilon-caprolactone); Composite; Morphology; Scaffold
资金
- New Energy and Industrial Technology Development Organization, Japan
Hydroxyapatite (HAp)/biodegradable poly(L-lactide-co-epsilon-caprolactone) (P(LA/CL)) composite microparticles were fabricated as an injectable scaffold via the Pickering emulsion route in the absence of any molecular surfactants. A stable oil in water emulsion was obtained using water dispersed HAp nanocrystals as the particulate emulsifier and a dichloromethane (CH2Cl2) solution of P(LA/CL) as the oil phase. The concentration-viscosity relationship of the P(LA/CL) solution and its influence on the formation of a stable emulsion were investigated. The dependence of homogenization on the concentration of the P(LA/CL) solution and shear speed of homogenization was also evaluated. HAp/P(LA/CL) microparticles of various morphologies, such as plates and spheres, or with various surface morphologies were realized through adjustment of the concentration and composition of the P(LA/CL) solution. The microparticles were observed by optical microscopy and scanning electronic microscopy and their size distributions measured using a microparticle size analyzer. The weight percentages of HAp nanocrystals on the HAp/P(LA/CL) microparticles of different average sizes were measured by thermogravimetric analysis. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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